J Reprod Med. Sep;47(9) Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement. Heller DS (1). Case Report. Hidradenitis Suppurativa: The Third Cause of Vulva Carcinoma. Ineke Janse1*, Gilles Diercks1,2, Jan Doff2, Marian Mourits3 and. Vulvar Hidradenitis Suppurativa: Is the Mass. Malignant? Siew-Fei Ngu, MBBS;1 Mandy M. Y. Chu, MBBS;1 Philip P. C. Ip, MBChB;2. Hextan Y. S. Ngan, MD1.

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Patient underwent a vulvar biopsy which revealed a focus of a well-differentiated, keratinizing squamous cell carcinoma.

Hidradenitis Suppurativa: The Third Cause of Vulva Carcinoma

Inflammation and eventual destruction of glands appear to be a secondary part of the disease process. A retrospective review of the histology of resections for vulvar HS was performed, and a battery of immunohistochemical stains was performed.

Discussion Our case highlights a rare vulvzr of long-standing poorly controlled hidradenitis suppurativa: At the completion of the procedure, 4 Jackson-Pratt drains were placed 2 in bilateral inguinal node dissection and 2 in reconstructive flap. Journal List Gynecol Oncol Rep v.

An abscess was suspected in the context of a HS whereupon a general surgeon performed an incision and drainage.

Hidradenitis suppurativa HS is an uncommon skin condition that affects the vulva and other parts of the skin, particularly the groin, under the pubic hair, armpits and under the breasts. Chronic hidradenitis suppurativa; Sclerosus vulvae; Vulvar cancer.


The patient’s external genitalia showed areas affected by severe, chronic hidradenitis suppurativa with marked hyperkeratosis with darkened areas of fibrosis. Being overweight makes HS worse as well.

Home About Us Advertise Amazon. The Third Cause of Vulva Carcinoma. Squamous cell carcinoma complicating chronic suppurative hydradenitis. Patient had a subsequent PET scan which was negative for distant metastasis. Women do not have as much of this as men, however they do have vulvae and it is androgen that affects HS.

Histopathology showed negative SN and clear margins. Atypical cells with enlarged, irregular nuclei and mitoses. Please review our privacy policy. B Well-differentiated squamous cell carcinoma SCC. S is a reliable marker for the clear cells of eccrine glands. Squamous cell carcinoma arising in hidradenitis suppurativa.

CA and HMB were not reliable markers for apocrine or eccrine gland differentiation. In this obese patient undergoing vulvar reconstruction with superimposed hidradenitis suppurativa, the postoperative course was further complicated by surgical site infection requiring multiple debridement procedures and prolonged courses of IV antibiotics Vancomycin, Piperacillin, Tazobactam, Ceftrizone, Flagyl with twice daily dressing changes with Dakins solution Image 3.

Smokers sometimes find that quitting smoking cures their HS. Surgery Painful lumps can be lanced, or injected with cortisone. It has been theorized that these chronic insults to skin can lead to proliferative epidermal changes as well as malignancy Donsky and Mendelson,Anstey et al.

Thirteen cases were available for review.


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Articles from Gynecologic Oncology Reports are provided here courtesy of Elsevier. Status post radical hemivulvectomy creating a large defect that required intervention by plastic surgery. Initially is a painful nodule of groin or axilla that may involute slowly or produce a foul smelling discharge due to anaerobes May produce abscess, fistula and scarring Late changes are a complex interconnecting system of sinuses extending deeply into the dermis and subcutaneous fat with extensive dense fibrosis Patients have increased risk of squamous cell cancinoma of skin, usually men with chronic disease of anogenital region, tumors are HPV related Dermatology ; A chronic, relapsing, suppurative inflammation of the terminal hair follicle in areas of apocrine glands: See Caring for your skin down there.

In fact they usually have normal hormone levels. Open in a separate window.

Apocrine glands, when present, were away from active inflammation. HS is made worse by male hormone testosterone. Squamous cell carcinoma as a complication of hidradenitis suppurativa.

Cases of vulvar HS showed a majority of eccrine glands in active areas. In addition, infliximab therapy was considered however the patient declined due to potential associated side effects.